Pep-Even™ (Tetrapeptide-30)

Description

Tetrapeptide-30 is a brightening and anti-discoloration peptide designed to target dark spots, post-inflammatory hyperpigmentation (PIH), melasma, and uneven skin tone.The liquid form is a pre-dissolved solution, making it easy to use in any water-based formulation without dissolving powders.

It works by inhibiting key pathways involved in melanin formation and blocking inflammatory signals that cause stubborn dark patches. It is Gentle, stable, and suitable for all skin types, including sensitive or acne-prone skin. The liquid form is convenient for use in formulations and typically appears as a clear, free-flowing liquid.

What it is and how it works Composition: A synthetic tetrapeptide (a peptide made of four amino acids) with the sequence PKEK.

Mechanism:Inhibits the enzyme tyrosinase, which is crucial for melanin production.Reduces the transfer of melanosomes from melanocytes to keratinocytes.Helps to reduce skin irritation and inflammation by decreasing the expression of genes for inflammatory markers like IL-6 and TNF-α.

Benefits: Provides skin-brightening and anti-spot effects, balances skin tone, and soothes the skin.

MECHANISM OF ACTION (IN DETAIL)

Tetrapeptide-30 works through multiple biochemical pathways:

1. Down-regulation of MITF

MITF (Microphthalmia-associated transcription factor) is the master switch that tells melanocytes to start producing melanin.
Tetrapeptide-30 suppresses MITF activity, preventing overproduction of melanin.

2. Tyrosinase inhibition

Tyrosinase is the key enzyme in melanin synthesis.
Tetrapeptide-30 reduces tyrosinase expression, leading to lighter and more uniform skin tone.

3. Anti-inflammatory modulation

By reducing cytokines, prostaglandins, and nitric oxide production, it minimizes the inflammatory signals that cause:
• Acne dark marks
• Razor bumps hyperpigmentation
• Sun-induced hyperpigmentation
• Chemical-burn scars

4. Melanosome-transfer reduction

Tetrapeptide-30 slows the transfer of melanin-containing melanosomes to keratinocytes, preventing visible darkening on the skin surface.

5. Prevents recurrence of pigmentation

Because it works on the root trigger (inflammation + melanocyte signaling), it helps prevent future discoloration.

BENEFITS

✔ Reduces dark spots and hyperpigmentation
✔ Targets melasma and acne marks
✔ Brightens and evens skin tone
✔ Prevents new pigmentation from forming
✔ Anti-inflammatory — reduces redness
✔ Gentle and safe for long-term use
✔ Works well with other brightening ingredients

Tetrapeptide-30 is especially effective for stubborn pigmentation, underarm darkness, inner thigh darkness, and hormonal melasma.

INGREDIENT INFORMATION

CAS No: 1036207-61-0
INCI: Tetrapeptide-30, Water, Glycerine
Percentage Purity: 99% 
Colour & Appearance: Colourless liquid
Recommended Usage Rate: 0.5 – 5% 
Solubility: water-soluble
Stable in pH Range:  4.5 – 6.5
Mixing Method:
Dissolve into the oil phase at low heat. Add antioxidants for stability. Avoid high temperatures.

COMPATIBILITY WITH OTHER ACTIVES

Tetrapeptide-30 is highly compatible with:

Brightening:
• Alpha arbutin
• Kojic acid & kojic dipalmitate
• Tranexamic acid
• Vitamin C derivatives (MAP, SAP, EAA, Ascorbyl glucoside)
• Niacinamide
• Licorice extract
• Glutathione
• Nonapeptide-1

Hydration / Barrier:
• Hyaluronic acid
• Panthenol
• Beta glucan
• Allantoin

Avoid:
✖ Strong acids (AHA/BHA with pH < 3.5)
✖ Copper-based actives

APPLICATIONS (PRODUCT TYPES)

Ideal for use in:
• Brightening & glow serums
• Underarm whitening creams
• Dark spot correctors
• Pigmentation treatment gels
• Melasma creams
• Acne-PIH treatment formulas
• Body brightening lotions
• Face creams & moisturizers
• Even-tone toners & essences

Packaging:

Packaged in airtight, UV-safe bottles to maintain peptide integrity and prevent degradation.

Recommended Storage:

Store in a cool, dry environment
• Refrigeration highly recommended (extends peptide life)
• Keep away from heat and sunlight
• Ensure air-tight closure to prevent degradation
• Do not mix with strong oxidizing agents

(Current lot will expire August 2028)

DISCLAIMER:

• DAKITZ NATURAL PRODUCTS are for cosmetic and personal care formulations and are meant for external use only, unless otherwise stated.

• This information is not intended to diagnose, treat, cure, or prevent any condition.

• Kindly research, test, and understand ingredients before purchasing.

• If you are not advanced in formulating, we recommend working with a chemist or professional formulator.