Activated Retinol-Granactive Retinoid (HPR)

Description

Activated Retinol refers to a form of vitamin A derivative that is biologically active and ready for the skin to use, unlike pure retinol which needs to be converted into retinoic acid in the skin.
Granactive Retinoid (also known as Hydroxypinacolone Retinoate or HPR) is a next-generation retinoid designed to provide similar anti-aging benefits as traditional retinoids but with less irritation.

This is one of the most bio-available, non-prescription forms of Vitamin-A sold in cosmetics. It decreases the effects of UV-induced skin damage and helps clear acne-related symptoms. Granactive Retinoate regulates the metabolism of the epidermis and stratum corneum. In addition, it has the function of reducing sebum overflow, diluting epidermal pigment, preventing skin aging, preventing acne, and whitening and lightening spots.
• Type: Vitamin A derivative
• Forms: Usually found as a powder, oil solution, or serum-ready liquid
• Stability: More stable than retinol, less likely to oxidize

Note: Granactive Retinoid is considered non-prescription in many regions and is more gentle than tretinoin.

Recommended in nighttime application, co-formulated with other active ingredients, photo stabilizers, and even sunscreens for daily wear
Recommended to formulate this product in a manner that avoids infusing air/oxygen into the final cosmetic product. Like all retinoids, the highly specific set of conjugated double bonds is susceptible to oxidation, antioxidants like vitamin E are suggested.
Promotes keratin metabolism, clears pores and treats acne, and improves skin roughness
Brightens skin tone, and reduces the appearance of fine lines and wrinkles.

BENEFITS INCLUDES

Granactive Retinoid / Activated Retinol provides a wide range of skin benefits:
1. Anti-aging:
• Reduces fine lines and wrinkles
• Improves skin firmness and elasticity

2. Skin texture & tone:
• Smooths rough skin
• Evens out pigmentation and dark spots

3. Acne control:
• Helps unclog pores
• Reduces formation of acne lesions

4. Gentler than traditional retinoids:
• Less irritation, redness, and peeling
• Can be used by sensitive skin types

5. Collagen synthesis:
• Stimulates collagen production, supporting skin structure

INGREDIENT INFORMATION

CAS No: 893412-73-2
INCI: Hydroxypinacolone Retinoate
Active Percentage : 10%
Colour & Appearance: Yellow to pale yellow oil                                                 Solubility: Oil-soluble
Stable in pH Range: Best used in pH 5.0 – 7.0
Recommended Usage Rate: 0.2% – 2% (depending on formulation type) Concentrations:
• Low (0.1–0.3%) – Gentle, suitable for sensitive or new users
• Medium (0.5%) – Regular anti-aging and acne treatment
• High (1%) – Stronger effect, usually under professional supervision
Mixing Method:
Dissolve into the oil phase at low heat. Add antioxidants for stability. Avoid high temperatures.

Applications

Granactive Retinoid can be used in:
• Serums – Most common form
• Creams & lotions – Often combined with moisturizers to reduce irritation
• Oil-based formulations – For higher stability
• Professional skin treatments – Used in controlled concentrations by dermatologists

Safety & Precautions

• Never apply pure 10% HPR directly to the skin                                                        • Avoid during pregnancy or breastfeeding (like all retinoids)                                  • Can cause mild redness, dryness, or tingling at the start
• Use sunscreen daily
• Layering with strong acids (AHA/BHA) may increase irritation

Packaging:

Our activated retinol is package in amber plastic or dark glass bottles to protect from light and to avoid spillage.

Recommended Storage:

Sensitive to light- Store in dark, cool conditions and dry place away from direct sunlight and moisture in an airtight container.
(Current lot will expire August 2028)

DISCLAIMER:

• DAKITZ NATURAL PRODUCTS are for cosmetic and personal care formulations and are meant for external use only, unless otherwise stated.

• This information is not intended to diagnose, treat, cure, or prevent any condition.

• Kindly research, test, and understand ingredients before purchasing.

• If you are not advanced in formulating, we recommend working with a chemist or professional formulator.