Nonapeptide-1 (Pep®-Radiance) – Melanostatine

Description

Pep®-Radiance (Nonapeptide-1) is an advanced skin-brightening peptide used in cosmetic formulations aimed at reducing the appearance of dark spots, improving overall skin tone, and enhancing radiance. It is popular in serums, creams, and leave-on treatments due to its high efficacy and gentle nature.

Liquid Nonapeptide-1 is a pre-dissolved brightening peptide solution with special high concentration 2500ppm, It functions as a melanin-inhibiting peptide, blocking α-MSH from binding to the melanocyte receptors (MC1-R), therefore slowing melanin production.

It is gentle, non-irritating, suitable for all skin types for long-term use, and works well in leave-on formulations.

MECHANISM OF ACTION (How It Works)

Nonapeptide-1 targets the melanocortin-1 receptor (MC1-R) on melanocytes.
It prevents α-MSH from attaching, which:

✔ reduces melanin synthesis
✔ slows down dark spot formation
✔ helps the skin maintain an even tone

Unlike strong actives, it brightens without bleaching or irritation.

• BENEFITS INCLUDES1. Reduces hyperpigmentation
  2. Brightens uneven skin tone
  3. Reduces dark marks, melasma, sun spots
  4. Safe alternative to hydroquinone
  5. Suitable for sensitive skin
  6. Hydrating base (if in glycerin/propylene glycol)
  7. Boosts radiance and clarity

• INGREDIENT INFORMATION

  INCI: Nonapeptide-1
  Concentration: 2500ppm
  Appearance: Clear to slightly opalescent liquid
  pH Range: 4.0 – 6.0 (Do Not use below 3.5, peptides can break down)
  Solubility: Water-soluble
  Recommended Usage Rate: 0.1% – 1% 
  Heat Sensitivity: Add during the cool-down phase below 40°C to preserve peptide activity

FORMULATION GUIDELINES

• Add to the water phase or during cool-down

• Compatible with most water-based and emulsion systems

• Works well in serums, lotions, creams, essences, and ampoule

• preserve peptide activity

COMPATIBILITY

Compatible with:
✔ Alpha arbutin
✔ Kojic acid & Kojic dipalmitate
✔ Tranexamic acid
✔ Niacinamide
✔ Vitamin C derivatives
✔ Glutathione
✔ Hyaluronic acid
✔ Beta-glucan

Avoid:
✖ Very acidic products (AHA/BHA < pH 3)
✖ Strong oxidizers

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USES (FORMULATION APPLICATIONS)

Ideal for:
• Brightening serums
• Dark spot correctors
• Underarm/bikini brightening
• Face creams & lotions
• Melasma treatments
• Toners / essence
• Anti-aging serums

PACKAGING

Packaged in airtight, UV-safe bottles to maintain peptide integrity and prevent degradation.

RECOMMENDED STORAGE

Store in a cool, dry place, tightly sealed, away from direct sunlight and heat sources.
(Current lot expires September 2028)

DISCLAIMER

DAKITZ NATURAL PRODUCTS are for cosmetic formulation and personal care product development only.
They are for external use unless stated otherwise.
This information is not intended to diagnose, treat, cure, or prevent any skin condition.
Usage must comply with your region’s cosmetic standards and regulations.
Please research, test, and understand all ingredients before purchase.
If you are not advanced in formulating, please work with a professional chemist or certified formulator.